A revised model for the deposition and clearance of inhaled particles in human extra-thoracic airways

Jennifer R.H. Smith*, Alan Birchall, George Etherington, Nobuhito Ishigure, Michael Bailey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The International Commission on Radiological Protection (ICRP) Task Group that developed the Human Respiratory Tract Model for Radiological Protection (HRTM) identified a lack of published information on aspects of the clearance of inhaled particles deposited in the human nasal passage. Using the results of a recent human volunteer study on the clearance of inhaled particles from the nose, a revised model of clearance from the extra-thoracic (ET) airways has been developed that addresses important issues for which simplifying assumptions had to be made in the ICRP Publication 66 HRTM ET model. This ET clearance model has been adopted by ICRP for inclusion in the revised HRTM. The derivation of the model and parameter values from the experimental data are explained.

Original languageEnglish
Article numbernct218
Pages (from-to)135-147
Number of pages13
JournalRadiation Protection Dosimetry
Issue number2
Publication statusPublished - Jan 2014

Bibliographical note

Funding Information:
The volunteer studies discussed in this paper were supported by part funding from the European Commission (contract no. F14P CT950026 ‘Inhalation of Radionuclides’) and British Nuclear Fuels plc (agreement number BW4/15822). The ET clearance modelling work was supported through the Joint Coordinating Committee on Radiation Effects Research (JCCRER) supported by the governments of the Russian Federation and the United States of America and managed by the U.S. Department of Energy (cooperative agreement DEFC0397 AF21354). The compilation of this publication was supported by funding from the National Institute for Health Research (NIHR project 102082, ‘Inhalation Studies’).


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