A review of mortality due to Clostridium difficile infection

J. A. Karas*, David Enoch, S. H. Aliyu

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    110 Citations (Scopus)


    In this review we examine published literature to ascertain mortality in relation to Clostridium difficile infection (CDI) and the factors associated with mortality. In the 27 studies that had sufficient data, there were 10975 cases of CDI with great heterogeneity in the methods for reporting mortality. We calculated the overall associated mortality to be at least 5.99% within 3 months of diagnosis. The most important finding is that higher mortality is associated with advanced age, being 13.5% in patients over 80 years. Studies performed after 2000 had a significantly higher mortality than those before this date. We propose minimum standards for reporting mortality in future studies.

    Original languageEnglish
    Pages (from-to)1-8
    Number of pages8
    JournalJournal of Infection
    Issue number1
    Publication statusPublished - Jul 2010


    • Clostridium difficile
    • Hospital acquired infection
    • Mortality
    • Nosocomial infections
    • Pseudomembranous colitis


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