A rare case of Salmonella Paratyphi C osteomyelitis: A genetic analysis and review of Salmonella osteomyelitis in England

William Hurt; Jim Stephenson; Jon Hutchinson; Gauri Godbole; Marie Anne Chattaway

doi:10.1016/j.diagmicrobio.2022.115877

A rare case of Salmonella Paratyphi C osteomyelitis: A genetic analysis and review of Salmonella osteomyelitis in England

William Hurt^*
, Jim Stephenson
, Jon Hutchinson
, Gauri Godbole
, Marie Anne Chattaway

^*Corresponding author for this work

Gastrointestinal Infections

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

128 Downloads (Pure)

Abstract

Salmonella osteomyelitis is rare in patients without sickling hemoglobinopathies. Invasive disease caused by Salmonella Paratyphi C is rarer still with only one case reported in the United Kingdom in the last 15 years. We report a case of relapsing S. Paratyphi C osteomyelitis in a newly diagnosed diabetic patient from Ghana. Our patient was initially treated successfully with surgical debridement followed by 6 weeks of IV ceftriaxone before recrudescence 9 months later. Due to the rarity of S. Paratyphi C and the lack of recent travel, genomic analysis was undertaken to assess possible sources with the closest related strain being from Cote d'Ivoire. The patient had likley picked up the strain several years before presentation. We review current Salmonella osteomyelitis literature and audit all cases referred to the England and Wales Salmonella national reference laboratory over the last 15 years.

Original language	English
Article number	115877
Journal	Diagnostic Microbiology and Infectious Disease
Volume	105
Issue number	3
Early online date	6 Dec 2022
DOIs	https://doi.org/10.1016/j.diagmicrobio.2022.115877
Publication status	Published - Mar 2023

Bibliographical note

Funding Information: Not applicable / no funding received.
WH has received speaker fees from Gilead Sciences.

Open Access: This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/)

Publisher Copyright: © 2022 The Authors. Published by Elsevier Inc.

Citation: William Hurt, Jim Stephenson, Jon Hutchinson, Gauri Godbole, Marie Anne Chattaway, A rare case of Salmonella Paratyphi C osteomyelitis: A genetic analysis and review of Salmonella osteomyelitis in England, Diagnostic Microbiology and Infectious Disease, Volume 105, Issue 3, 2023, 115877, ISSN 0732-8893, https://doi.org/10.1016/j.diagmicrobio.2022.115877.

DOI: https://doi.org/10.1016/j.diagmicrobio.2022.115877

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Paratyphi C
Salmonella
genomics
osteomyelitis

Access to Document

10.1016/j.diagmicrobio.2022.115877Licence: CC BY-NC-ND

Hurt2023ARareCaseOfSalmonellaParatyphiCOsteomyelitisAGeneticAnalysisAndReviewDiagnMicrobiolInfectDisFinal published version, 574 KBLicence: CC BY-NC-ND

Cite this

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title = "A rare case of Salmonella Paratyphi C osteomyelitis: A genetic analysis and review of Salmonella osteomyelitis in England",

abstract = "Salmonella osteomyelitis is rare in patients without sickling hemoglobinopathies. Invasive disease caused by Salmonella Paratyphi C is rarer still with only one case reported in the United Kingdom in the last 15 years. We report a case of relapsing S. Paratyphi C osteomyelitis in a newly diagnosed diabetic patient from Ghana. Our patient was initially treated successfully with surgical debridement followed by 6 weeks of IV ceftriaxone before recrudescence 9 months later. Due to the rarity of S. Paratyphi C and the lack of recent travel, genomic analysis was undertaken to assess possible sources with the closest related strain being from Cote d'Ivoire. The patient had likley picked up the strain several years before presentation. We review current Salmonella osteomyelitis literature and audit all cases referred to the England and Wales Salmonella national reference laboratory over the last 15 years.",

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author = "William Hurt and Jim Stephenson and Jon Hutchinson and Gauri Godbole and Chattaway, \{Marie Anne\}",

note = "Funding Information: Not applicable / no funding received. WH has received speaker fees from Gilead Sciences. Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Publisher Copyright: {\textcopyright} 2022 The Authors. Published by Elsevier Inc. Citation: William Hurt, Jim Stephenson, Jon Hutchinson, Gauri Godbole, Marie Anne Chattaway, A rare case of Salmonella Paratyphi C osteomyelitis: A genetic analysis and review of Salmonella osteomyelitis in England, Diagnostic Microbiology and Infectious Disease, Volume 105, Issue 3, 2023, 115877, ISSN 0732-8893, https://doi.org/10.1016/j.diagmicrobio.2022.115877. DOI: https://doi.org/10.1016/j.diagmicrobio.2022.115877",

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AB - Salmonella osteomyelitis is rare in patients without sickling hemoglobinopathies. Invasive disease caused by Salmonella Paratyphi C is rarer still with only one case reported in the United Kingdom in the last 15 years. We report a case of relapsing S. Paratyphi C osteomyelitis in a newly diagnosed diabetic patient from Ghana. Our patient was initially treated successfully with surgical debridement followed by 6 weeks of IV ceftriaxone before recrudescence 9 months later. Due to the rarity of S. Paratyphi C and the lack of recent travel, genomic analysis was undertaken to assess possible sources with the closest related strain being from Cote d'Ivoire. The patient had likley picked up the strain several years before presentation. We review current Salmonella osteomyelitis literature and audit all cases referred to the England and Wales Salmonella national reference laboratory over the last 15 years.

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A rare case of Salmonella Paratyphi C osteomyelitis: A genetic analysis and review of Salmonella osteomyelitis in England

Abstract

Bibliographical note

UN SDGs

Keywords

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