TY - JOUR
T1 - A randomized comparative study of sulbactam plus ampicillin vs. Metronidazole plus cefotaxime in the management of acute appendicitis in children
AU - Foster, M. C.
AU - Kapila, Leela
AU - Morris, D. L.
AU - Slack, R. C.
PY - 1986/11
Y1 - 1986/11
N2 - Sulbactam is a P-lactamase inhibitor that, when combined with ampicillin, gives the latter antibiotic a broad spectrum of activity, making it suitable for use as a prophylactic agent in acute appendicitis. In a single-blind, randomized trial, the efficacy of sulbactam plus ampicillin was compared with that of metronidazole plus cefotaxime. Thirty-five children undergoing appendectomy received intravenous sulbactam and ampicillin, while 38 children received metronidazole and cefotaxime. Single doses were given unless the appendix was considered gangrenous or perforated, in which case the drugs were administered for 72 hr. There were three wound infections in the group given sulbactam and ampicillin and five in the group given metronidazole and cefotaxime. The combination of sulbactam and ampicillin was well tolerated and appeared to be at least as effective as that of metronidazole and cefotaxime in the prevention of sepsis following appendectomy.
AB - Sulbactam is a P-lactamase inhibitor that, when combined with ampicillin, gives the latter antibiotic a broad spectrum of activity, making it suitable for use as a prophylactic agent in acute appendicitis. In a single-blind, randomized trial, the efficacy of sulbactam plus ampicillin was compared with that of metronidazole plus cefotaxime. Thirty-five children undergoing appendectomy received intravenous sulbactam and ampicillin, while 38 children received metronidazole and cefotaxime. Single doses were given unless the appendix was considered gangrenous or perforated, in which case the drugs were administered for 72 hr. There were three wound infections in the group given sulbactam and ampicillin and five in the group given metronidazole and cefotaxime. The combination of sulbactam and ampicillin was well tolerated and appeared to be at least as effective as that of metronidazole and cefotaxime in the prevention of sepsis following appendectomy.
UR - http://www.scopus.com/inward/record.url?scp=84960604583&partnerID=8YFLogxK
U2 - 10.1093/clinids/8.Supplement_5.S634
DO - 10.1093/clinids/8.Supplement_5.S634
M3 - Article
C2 - 3026017
AN - SCOPUS:84960604583
SN - 0162-0886
VL - 8
SP - 8
EP - 638
JO - Reviews of Infectious Diseases
JF - Reviews of Infectious Diseases
ER -