A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus

Elizabeth R. Allen; Stefanie A. Krumm; Jayna Raghwani; Steinar Halldorsson; Angela Elliott; Victoria A. Graham; Elina Koudriakova; Karl Harlos; Daniel Wright; George M. Warimwe; Benjamin Brennan; Juha T. Huiskonen; Stuart Dowall; Richard M. Elliott; Oliver G. Pybus; Dennis R. Burton; Roger Hewson; Katie J. Doores; Thomas A. Bowden

doi:10.1016/j.celrep.2018.12.001

A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus

Elizabeth R. Allen, Stefanie A. Krumm, Jayna Raghwani, Steinar Halldorsson, Angela Elliott, Victoria A. Graham, Elina Koudriakova, Karl Harlos, Daniel Wright, George M. Warimwe, Benjamin Brennan, Juha T. Huiskonen, Stuart Dowall, Richard M. Elliott, Oliver G. Pybus, Dennis R. Burton, Roger Hewson, Katie J. Doores^*, Thomas A. Bowden

^*Corresponding author for this work

Research & Technical Staff

Research output: Contribution to journal › Article › peer-review

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Abstract

Allen et al. reveal a molecular basis of antibody-mediated neutralization of Rift Valley fever virus, an important human and animal pathogen. They isolate and demonstrate the protective efficacy of a monoclonal antibody in a murine model of virus infection, providing a blueprint for rational therapeutic and vaccine design.

Original language	English
Pages (from-to)	3750-3758.e4
Journal	Cell Reports
Volume	25
Issue number	13
DOIs	https://doi.org/10.1016/j.celrep.2018.12.001
Publication status	Published - 26 Dec 2018

Bibliographical note

Publisher Copyright:
© 2018 The Author(s)

Keywords

Rift Valley fever virus
antibody
antiviral
bunyavirus
immune response
neutralization
phlebovirus
structure
vaccine
virus-host interactions

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2018.12.001

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Allen, E. R., Krumm, S. A., Raghwani, J., Halldorsson, S., Elliott, A., Graham, V. A., Koudriakova, E., Harlos, K., Wright, D., Warimwe, G. M., Brennan, B., Huiskonen, J. T., Dowall, S., Elliott, R. M., Pybus, O. G., Burton, D. R., Hewson, R., Doores, K. J., & Bowden, T. A. (2018). A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus. Cell Reports, 25(13), 3750-3758.e4. https://doi.org/10.1016/j.celrep.2018.12.001

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title = "A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus",

abstract = "Allen et al. reveal a molecular basis of antibody-mediated neutralization of Rift Valley fever virus, an important human and animal pathogen. They isolate and demonstrate the protective efficacy of a monoclonal antibody in a murine model of virus infection, providing a blueprint for rational therapeutic and vaccine design.",

keywords = "Rift Valley fever virus, antibody, antiviral, bunyavirus, immune response, neutralization, phlebovirus, structure, vaccine, virus-host interactions",

author = "Allen, {Elizabeth R.} and Krumm, {Stefanie A.} and Jayna Raghwani and Steinar Halldorsson and Angela Elliott and Graham, {Victoria A.} and Elina Koudriakova and Karl Harlos and Daniel Wright and Warimwe, {George M.} and Benjamin Brennan and Huiskonen, {Juha T.} and Stuart Dowall and Elliott, {Richard M.} and Pybus, {Oliver G.} and Burton, {Dennis R.} and Roger Hewson and Doores, {Katie J.} and Bowden, {Thomas A.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s)",

year = "2018",

month = dec,

day = "26",

doi = "10.1016/j.celrep.2018.12.001",

language = "English",

volume = "25",

pages = "3750--3758.e4",

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Allen, ER, Krumm, SA, Raghwani, J, Halldorsson, S, Elliott, A, Graham, VA, Koudriakova, E, Harlos, K, Wright, D, Warimwe, GM, Brennan, B, Huiskonen, JT, Dowall, S, Elliott, RM, Pybus, OG, Burton, DR, Hewson, R, Doores, KJ & Bowden, TA 2018, 'A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus', Cell Reports, vol. 25, no. 13, pp. 3750-3758.e4. https://doi.org/10.1016/j.celrep.2018.12.001

TY - JOUR

T1 - A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus

AU - Allen, Elizabeth R.

AU - Krumm, Stefanie A.

AU - Raghwani, Jayna

AU - Halldorsson, Steinar

AU - Elliott, Angela

AU - Graham, Victoria A.

AU - Koudriakova, Elina

AU - Harlos, Karl

AU - Wright, Daniel

AU - Warimwe, George M.

AU - Brennan, Benjamin

AU - Huiskonen, Juha T.

AU - Dowall, Stuart

AU - Elliott, Richard M.

AU - Pybus, Oliver G.

AU - Burton, Dennis R.

AU - Hewson, Roger

AU - Doores, Katie J.

AU - Bowden, Thomas A.

PY - 2018/12/26

Y1 - 2018/12/26

N2 - Allen et al. reveal a molecular basis of antibody-mediated neutralization of Rift Valley fever virus, an important human and animal pathogen. They isolate and demonstrate the protective efficacy of a monoclonal antibody in a murine model of virus infection, providing a blueprint for rational therapeutic and vaccine design.

AB - Allen et al. reveal a molecular basis of antibody-mediated neutralization of Rift Valley fever virus, an important human and animal pathogen. They isolate and demonstrate the protective efficacy of a monoclonal antibody in a murine model of virus infection, providing a blueprint for rational therapeutic and vaccine design.

KW - Rift Valley fever virus

KW - antibody

KW - antiviral

KW - bunyavirus

KW - immune response

KW - neutralization

KW - phlebovirus

KW - structure

KW - vaccine

KW - virus-host interactions

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U2 - 10.1016/j.celrep.2018.12.001

DO - 10.1016/j.celrep.2018.12.001

M3 - Article

C2 - 30590046

AN - SCOPUS:85058422412

SN - 2211-1247

VL - 25

SP - 3750-3758.e4

JO - Cell Reports

JF - Cell Reports

IS - 13

ER -

A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus

Abstract

Bibliographical note

Keywords

UN SDGs

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