A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

Jennifer Mattock; Marie Anne Chattaway; Hassan Hartman; Timothy J. Dallman; Anthony M. Smith; Karen Keddy; Liljana Petrovska; Emma J. Manners; Sanelisiwe T. Duze; Shannon Smouse; Nomsa Tau; Ruth Timme; Dave J. Baker; Alison E. Mather; John Wain; Gemma C. Langridge

doi:10.3201/eid3004.231031

A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

Jennifer Mattock^*, Marie Anne Chattaway, Hassan Hartman, Timothy J. Dallman, Anthony M. Smith, Karen Keddy, Liljana Petrovska, Emma J. Manners, Sanelisiwe T. Duze, Shannon Smouse, Nomsa Tau, Ruth Timme, Dave J. Baker, Alison E. Mather, John Wain, Gemma C. Langridge

^*Corresponding author for this work

Gastrointestinal Bacteria WGS

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Salmonella enterica serovar Infantis presents an ever-increasing threat to public health because of its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). We analyzed whole-genome sequences of 5,284 Salmonella Infantis strains from 74 countries, isolated during 1989-2020 from a wide variety of human, animal, and food sources, to compare genetic phylogeny, AMR determinants, and plasmid presence. The global Salmonella Infantis population structure diverged into 3 clusters: a North American cluster, a European cluster, and a global cluster. The levels of AMR varied by Salmonella Infantis cluster and by isolation source; 73% of poultry isolates were multidrug resistant, compared with 35% of human isolates. This finding correlated with the presence of the pESI megaplasmid; 71% of poultry isolates contained pESI, compared with 32% of human isolates. This study provides key information for public health teams engaged in reducing the spread of this pathogen.

Original language	English
Pages (from-to)	701-710
Number of pages	10
Journal	Emerging Infectious Diseases
Volume	30
Issue number	4
DOIs	https://doi.org/10.3201/eid3004.231031
Publication status	Published - Apr 2024

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© 2024 Centers for Disease Control and Prevention (CDC). All rights reserved.

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Mattock, J., Chattaway, M. A., Hartman, H., Dallman, T. J., Smith, A. M., Keddy, K., Petrovska, L., Manners, E. J., Duze, S. T., Smouse, S., Tau, N., Timme, R., Baker, D. J., Mather, A. E., Wain, J., & Langridge, G. C. (2024). A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen. Emerging Infectious Diseases, 30(4), 701-710. https://doi.org/10.3201/eid3004.231031

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title = "A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen",

abstract = "Salmonella enterica serovar Infantis presents an ever-increasing threat to public health because of its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). We analyzed whole-genome sequences of 5,284 Salmonella Infantis strains from 74 countries, isolated during 1989-2020 from a wide variety of human, animal, and food sources, to compare genetic phylogeny, AMR determinants, and plasmid presence. The global Salmonella Infantis population structure diverged into 3 clusters: a North American cluster, a European cluster, and a global cluster. The levels of AMR varied by Salmonella Infantis cluster and by isolation source; 73% of poultry isolates were multidrug resistant, compared with 35% of human isolates. This finding correlated with the presence of the pESI megaplasmid; 71% of poultry isolates contained pESI, compared with 32% of human isolates. This study provides key information for public health teams engaged in reducing the spread of this pathogen.",

author = "Jennifer Mattock and Chattaway, {Marie Anne} and Hassan Hartman and Dallman, {Timothy J.} and Smith, {Anthony M.} and Karen Keddy and Liljana Petrovska and Manners, {Emma J.} and Duze, {Sanelisiwe T.} and Shannon Smouse and Nomsa Tau and Ruth Timme and Baker, {Dave J.} and Mather, {Alison E.} and John Wain and Langridge, {Gemma C.}",

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doi = "10.3201/eid3004.231031",

language = "English",

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Mattock, J, Chattaway, MA , Hartman, H, Dallman, TJ, Smith, AM, Keddy, K, Petrovska, L, Manners, EJ, Duze, ST, Smouse, S, Tau, N, Timme, R, Baker, DJ, Mather, AE, Wain, J & Langridge, GC 2024, 'A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen', Emerging Infectious Diseases, vol. 30, no. 4, pp. 701-710. https://doi.org/10.3201/eid3004.231031

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AU - Smith, Anthony M.

AU - Keddy, Karen

AU - Petrovska, Liljana

AU - Manners, Emma J.

AU - Duze, Sanelisiwe T.

AU - Smouse, Shannon

AU - Tau, Nomsa

AU - Timme, Ruth

AU - Baker, Dave J.

AU - Mather, Alison E.

AU - Wain, John

AU - Langridge, Gemma C.

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AB - Salmonella enterica serovar Infantis presents an ever-increasing threat to public health because of its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). We analyzed whole-genome sequences of 5,284 Salmonella Infantis strains from 74 countries, isolated during 1989-2020 from a wide variety of human, animal, and food sources, to compare genetic phylogeny, AMR determinants, and plasmid presence. The global Salmonella Infantis population structure diverged into 3 clusters: a North American cluster, a European cluster, and a global cluster. The levels of AMR varied by Salmonella Infantis cluster and by isolation source; 73% of poultry isolates were multidrug resistant, compared with 35% of human isolates. This finding correlated with the presence of the pESI megaplasmid; 71% of poultry isolates contained pESI, compared with 32% of human isolates. This study provides key information for public health teams engaged in reducing the spread of this pathogen.

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A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

Abstract

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