A non-sense mutation in Cd36 gene is associated with protection from severe malaria

Arnab Pain; Britta C. Urban; Oscar Kai; Climent Casals-Pascual; Juma Shafi; Kevin Marsh; David J. Roberts

doi:10.1016/S0140-6736(00)04662-6

A non-sense mutation in Cd36 gene is associated with protection from severe malaria

Arnab Pain, Britta C. Urban, Oscar Kai, Climent Casals-Pascual, Juma Shafi, Kevin Marsh, David J. Roberts^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0·74, 95% CI 0·55-0·99; p=0·036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.

Original language	English
Pages (from-to)	1502-1503
Number of pages	2
Journal	The Lancet
Volume	357
Issue number	9267
DOIs	https://doi.org/10.1016/S0140-6736(00)04662-6
Publication status	Published - 12 May 2001
Externally published	Yes

Bibliographical note

Funding Information:
The work was supported by the Wellcome Trust, the Kenyan Medical Research Institute (KEMRI), and the National Blood Service, UK. We thank Brian Curtis (Wisconsin) for Naka (-) platelets. Sir EPA Abraham Trust supports BCU. KM is a Wellcome Trust Senior Fellow in Clinical Science.

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Cite this

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title = "A non-sense mutation in Cd36 gene is associated with protection from severe malaria",

abstract = "We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0·74, 95% CI 0·55-0·99; p=0·036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.",

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note = "Funding Information: The work was supported by the Wellcome Trust, the Kenyan Medical Research Institute (KEMRI), and the National Blood Service, UK. We thank Brian Curtis (Wisconsin) for Naka (-) platelets. Sir EPA Abraham Trust supports BCU. KM is a Wellcome Trust Senior Fellow in Clinical Science.",

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AU - Pain, Arnab

AU - Urban, Britta C.

AU - Kai, Oscar

AU - Casals-Pascual, Climent

AU - Shafi, Juma

AU - Marsh, Kevin

AU - Roberts, David J.

N1 - Funding Information: The work was supported by the Wellcome Trust, the Kenyan Medical Research Institute (KEMRI), and the National Blood Service, UK. We thank Brian Curtis (Wisconsin) for Naka (-) platelets. Sir EPA Abraham Trust supports BCU. KM is a Wellcome Trust Senior Fellow in Clinical Science.

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N2 - We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0·74, 95% CI 0·55-0·99; p=0·036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.

AB - We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0·74, 95% CI 0·55-0·99; p=0·036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.

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A non-sense mutation in Cd36 gene is associated with protection from severe malaria

Abstract

Bibliographical note

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