A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in China

Jin Hu Fan; Yu Qing Zhang; Su Sheng Shi; Yuan Jia Chen; Xing Hua Yuan; Li Ming Jiang; Shao Ming Wang; Li Ma; Yu Tong He; Chang Yan Feng; Xi Bin Sun; Qing Liu; Katrina Deloso; Yihebali Chi; You Lin Qiao

doi:10.18632/oncotarget.17599

A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in China

Jin Hu Fan, Yu Qing Zhang, Su Sheng Shi, Yuan Jia Chen, Xing Hua Yuan, Li Ming Jiang, Shao Ming Wang, Li Ma, Yu Tong He, Chang Yan Feng, Xi Bin Sun, Qing Liu, Katrina Deloso, Yihebali Chi, You Lin Qiao^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

Background: Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients. Methods: This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) retrospective study which collected GEP-NEN patients' information in tertiary referral hospitals. All 2010 inpatient GEP-NEN cases with confirmed pathology in the selected hospitals were included. The primary GEP-NEN sites were measured and the epidemiological and clinical information of each tumor site were compared. Results: The most common primary sites for GEP-NEN were the pancreas (31.5%) and rectum (29.6%), followed by the cardia (11.6%) and body (15.4%) of stomach. Small intestinal and colonic NENs took up a relatively small proportion of all patients. Pancreatic and rectal NENs, rather than cardiac and gastric body NENs, tended to be found in younger (P<0.001), female (P<0.001), urban (P<0.001) residents with a higher education level (P=0.032) and were also diagnosed at earlier stage (P<0.001) and lower grade (P<0.001). Surgery remained the primary treatment method in all groups. Conclusions:More studies on the commonality and heterogeneity of GEP-NENs are warranted to improve diagnosis efficiencies and treatment outcomes.

Original language	English
Pages (from-to)	71699-71708
Number of pages	10
Journal	Oncotarget
Volume	8
Issue number	42
DOIs	https://doi.org/10.18632/oncotarget.17599
Publication status	Published - 3 May 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© Fan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Keywords

Digestive system
Epidemiology
Neuroendocrine tumors
Retrospective study multicenter study

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10.18632/oncotarget.17599

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Fan, J. H., Zhang, Y. Q., Shi, S. S., Chen, Y. J., Yuan, X. H., Jiang, L. M., Wang, S. M., Ma, L., He, Y. T., Feng, C. Y., Sun, X. B., Liu, Q., Deloso, K., Chi, Y., & Qiao, Y. L. (2017). A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in China. Oncotarget, 8(42), 71699-71708. https://doi.org/10.18632/oncotarget.17599

@article{efd52d9fdf8442d78d3c055d54ae71d1,

title = "A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in China",

abstract = "Background: Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients. Methods: This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) retrospective study which collected GEP-NEN patients' information in tertiary referral hospitals. All 2010 inpatient GEP-NEN cases with confirmed pathology in the selected hospitals were included. The primary GEP-NEN sites were measured and the epidemiological and clinical information of each tumor site were compared. Results: The most common primary sites for GEP-NEN were the pancreas (31.5\%) and rectum (29.6\%), followed by the cardia (11.6\%) and body (15.4\%) of stomach. Small intestinal and colonic NENs took up a relatively small proportion of all patients. Pancreatic and rectal NENs, rather than cardiac and gastric body NENs, tended to be found in younger (P<0.001), female (P<0.001), urban (P<0.001) residents with a higher education level (P=0.032) and were also diagnosed at earlier stage (P<0.001) and lower grade (P<0.001). Surgery remained the primary treatment method in all groups. Conclusions:More studies on the commonality and heterogeneity of GEP-NENs are warranted to improve diagnosis efficiencies and treatment outcomes.",

keywords = "Digestive system, Epidemiology, Neuroendocrine tumors, Retrospective study multicenter study",

author = "Fan, \{Jin Hu\} and Zhang, \{Yu Qing\} and Shi, \{Su Sheng\} and Chen, \{Yuan Jia\} and Yuan, \{Xing Hua\} and Jiang, \{Li Ming\} and Wang, \{Shao Ming\} and Li Ma and He, \{Yu Tong\} and Feng, \{Chang Yan\} and Sun, \{Xi Bin\} and Qing Liu and Katrina Deloso and Yihebali Chi and Qiao, \{You Lin\}",

note = "Publisher Copyright: {\textcopyright} Fan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2017",

month = may,

day = "3",

doi = "10.18632/oncotarget.17599",

language = "English",

volume = "8",

pages = "71699--71708",

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T1 - A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in China

AU - Fan, Jin Hu

AU - Zhang, Yu Qing

AU - Shi, Su Sheng

AU - Chen, Yuan Jia

AU - Yuan, Xing Hua

AU - Jiang, Li Ming

AU - Wang, Shao Ming

AU - Ma, Li

AU - He, Yu Tong

AU - Feng, Chang Yan

AU - Sun, Xi Bin

AU - Liu, Qing

AU - Deloso, Katrina

AU - Chi, Yihebali

AU - Qiao, You Lin

N1 - Publisher Copyright: © Fan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2017/5/3

Y1 - 2017/5/3

N2 - Background: Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients. Methods: This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) retrospective study which collected GEP-NEN patients' information in tertiary referral hospitals. All 2010 inpatient GEP-NEN cases with confirmed pathology in the selected hospitals were included. The primary GEP-NEN sites were measured and the epidemiological and clinical information of each tumor site were compared. Results: The most common primary sites for GEP-NEN were the pancreas (31.5%) and rectum (29.6%), followed by the cardia (11.6%) and body (15.4%) of stomach. Small intestinal and colonic NENs took up a relatively small proportion of all patients. Pancreatic and rectal NENs, rather than cardiac and gastric body NENs, tended to be found in younger (P<0.001), female (P<0.001), urban (P<0.001) residents with a higher education level (P=0.032) and were also diagnosed at earlier stage (P<0.001) and lower grade (P<0.001). Surgery remained the primary treatment method in all groups. Conclusions:More studies on the commonality and heterogeneity of GEP-NENs are warranted to improve diagnosis efficiencies and treatment outcomes.

AB - Background: Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients. Methods: This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) retrospective study which collected GEP-NEN patients' information in tertiary referral hospitals. All 2010 inpatient GEP-NEN cases with confirmed pathology in the selected hospitals were included. The primary GEP-NEN sites were measured and the epidemiological and clinical information of each tumor site were compared. Results: The most common primary sites for GEP-NEN were the pancreas (31.5%) and rectum (29.6%), followed by the cardia (11.6%) and body (15.4%) of stomach. Small intestinal and colonic NENs took up a relatively small proportion of all patients. Pancreatic and rectal NENs, rather than cardiac and gastric body NENs, tended to be found in younger (P<0.001), female (P<0.001), urban (P<0.001) residents with a higher education level (P=0.032) and were also diagnosed at earlier stage (P<0.001) and lower grade (P<0.001). Surgery remained the primary treatment method in all groups. Conclusions:More studies on the commonality and heterogeneity of GEP-NENs are warranted to improve diagnosis efficiencies and treatment outcomes.

KW - Digestive system

KW - Epidemiology

KW - Neuroendocrine tumors

KW - Retrospective study multicenter study

UR - https://www.scopus.com/pages/publications/85039543145

U2 - 10.18632/oncotarget.17599

DO - 10.18632/oncotarget.17599

M3 - Article

C2 - 29069739

AN - SCOPUS:85039543145

SN - 1949-2553

VL - 8

SP - 71699

EP - 71708

JO - Oncotarget

JF - Oncotarget

IS - 42

ER -

A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in China

Abstract

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Keywords

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