A multi-centre clinical evaluation of reactive oxygen topical wound gel in 114 wounds

Matthew Dryden, A. Dickinson, J. Brooks, L. Hudgell, K. Saeed, K. F. Cutting

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


•Objective: This article reports the outcomes of the use of Surgihoney RO (SHRO), topical wound dressing in a multi-centre, international setting. The aims were to explore the clinical effects of SHRO, including a reduction in bacterial load and biofilm and improvement in healing in a variety of challenging non-healing and clinically infected wounds. • Method: This was a non-comparative evaluation, where both acute and chronic wounds with established delayed healing were treated with the dressing. Clinicians prospectively recorded wound improvement or deterioration, level of wound exudate, presence of pain, and presence of slough and necrosis. Analysis of this data provided information on clinical performance of the dressing. Semi-quantitative culture to assess bacterial bioburden was performed where possible. •Results: We recruited 104 patients, mean age 61 years old, with 114 wounds. The mean duration of wounds before treatment was 3.7 months and the mean duration of treatment was 25.7 days. During treatment 24 wounds (21%) healed and the remaining 90 (79%) wounds improved following application of the dressing. No deterioration in any wound was observed. A reduction in patient pain, level of wound exudate and in devitalised tissue were consistently reported. These positive improvements in wound progress were reflected in the wound cultures that showed a reduction in bacterial load in 39 out of the 40 swabs taken. There were two adverse events recorded: a stinging sensation following application of the dressing was experienced by 2 patients, and 2 elderly patients died of causes unrelated to the dressing or to the chronic wound. These patients' wounds and their response to SHRO have been included in the analysis. • Conclusion: SHRO was well tolerated and shows great promise as an effective potent topical antimicrobial in the healing of challenging wounds. •Declaration of interest: Matthew Dryden has become a shareholder in Matoke Holdings, the manufacturer of Surgihoney RO, since the completion of this study. Keith Cutting is a consultant to Matoke Holdings.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalJournal of wound care
Issue number3
Publication statusPublished - Mar 2016


  • Acute wound
  • Chronic wound
  • Clinical evaluation
  • RO surgihoney
  • Topical antimicrobial gel


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