A modified creatinine adjustment method to improve urinary biomonitoring of exposure to arsenic in drinking water

D. R.S. Middleton; M. J. Watts; Antony Fletcher; D. A. Polya

doi:10.1201/b20466-190

A modified creatinine adjustment method to improve urinary biomonitoring of exposure to arsenic in drinking water

D. R.S. Middleton, M. J. Watts, Antony Fletcher, D. A. Polya

Chemicals & Environmental Effects

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Spot urinary concentrations of arsenic (As) require adjustment for hydration variation. There is no consensus as to the most appropriate method. We compared the performance of creatinine (Cre), specific gravity (SG), osmolality and a modified variant of Cre adjustment on spot urinary As concentrations of 203 volunteers from the UK. Strength in correlation between drinking water total As and urinary non-arsenobetaine As was used to indicate good performance. Performance of the order: Cre (modified) > SG > osmolality > unadjusted > Cre (routine) was observed. Only Cre (modified) adjustment performed significantly better than unadjusted concentrations and both Cre (modified) and SG performed significantly better than Cre (routine). This is the first study to compare the performance of multiple hydration adjustments of urinary As on the basis of reflectance of external exposure and, importantly, allows others to apply this methodology to existing data without further measurements.

Original language	English
Title of host publication	Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
Editors	Prosun Bhattacharya, Gunnar Jacks, Jochen Bundschuh, Prosun Bhattacharya, Marie Vahter, Jerker Jarsjo, Jerker Jarsjo, Jurate Kumpiene, Arslan Ahmad, Charlotte Sparrenbom, Marinus Eric Donselaar, Jochen Bundschuh, Ravi Naidu, Ravi Naidu
Publisher	CRC Press/Balkema
Pages	406-408
Number of pages	3
ISBN (Print)	9781138029415
DOIs	https://doi.org/10.1201/b20466-190
Publication status	Published - 2016
Event	6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, Sweden Duration: 19 Jun 2016 → 23 Jun 2016

Publication series

Name	Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

Conference

Conference	6th International Congress on Arsenic in the Environment, AS 2016
Country/Territory	Sweden
City	Stockholm
Period	19/06/16 → 23/06/16

Bibliographical note

Funding Information:
DRSM was funded by NERC via a University of Manchester/BUFI (Centre for Environmental Geochemistry) PhD studentship (GA/125/017, BUFI Ref: S204.2). We thank Elliott Hamilton, Louise Ander, Andrew Marriott and Andrew Dunne (all BGS) and Giovanni Leonardi, Rebecca Close, Helen Crabbe, Karen Exley, Amy Rimell and Mike Studden (all PHE) for their involvement in the wider project. We thank Nigel Kendall and David Gardner from the University of Nottingham Biosciences for facilitating creatinine and osmolality measurements. Murray Lark, Chris Milne, Mark Cave and Simon Chenery from the BGS are thanked for advice

Publisher Copyright:
© 2016 Taylor & Francis Group, London.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Access to Document

10.1201/b20466-190

Cite this

Middleton, D. R. S., Watts, M. J., Fletcher, A., & Polya, D. A. (2016). A modified creatinine adjustment method to improve urinary biomonitoring of exposure to arsenic in drinking water. In P. Bhattacharya, G. Jacks, J. Bundschuh, P. Bhattacharya, M. Vahter, J. Jarsjo, J. Jarsjo, J. Kumpiene, A. Ahmad, C. Sparrenbom, M. E. Donselaar, J. Bundschuh, R. Naidu, & R. Naidu (Eds.), Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016 (pp. 406-408). (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016). CRC Press/Balkema. https://doi.org/10.1201/b20466-190

Middleton, D. R.S. ; Watts, M. J. ; Fletcher, Antony et al. / A modified creatinine adjustment method to improve urinary biomonitoring of exposure to arsenic in drinking water. Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. editor / Prosun Bhattacharya ; Gunnar Jacks ; Jochen Bundschuh ; Prosun Bhattacharya ; Marie Vahter ; Jerker Jarsjo ; Jerker Jarsjo ; Jurate Kumpiene ; Arslan Ahmad ; Charlotte Sparrenbom ; Marinus Eric Donselaar ; Jochen Bundschuh ; Ravi Naidu ; Ravi Naidu. CRC Press/Balkema, 2016. pp. 406-408 (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016).

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title = "A modified creatinine adjustment method to improve urinary biomonitoring of exposure to arsenic in drinking water",

abstract = "Spot urinary concentrations of arsenic (As) require adjustment for hydration variation. There is no consensus as to the most appropriate method. We compared the performance of creatinine (Cre), specific gravity (SG), osmolality and a modified variant of Cre adjustment on spot urinary As concentrations of 203 volunteers from the UK. Strength in correlation between drinking water total As and urinary non-arsenobetaine As was used to indicate good performance. Performance of the order: Cre (modified) > SG > osmolality > unadjusted > Cre (routine) was observed. Only Cre (modified) adjustment performed significantly better than unadjusted concentrations and both Cre (modified) and SG performed significantly better than Cre (routine). This is the first study to compare the performance of multiple hydration adjustments of urinary As on the basis of reflectance of external exposure and, importantly, allows others to apply this methodology to existing data without further measurements.",

author = "Middleton, {D. R.S.} and Watts, {M. J.} and Antony Fletcher and Polya, {D. A.}",

note = "Funding Information: DRSM was funded by NERC via a University of Manchester/BUFI (Centre for Environmental Geochemistry) PhD studentship (GA/125/017, BUFI Ref: S204.2). We thank Elliott Hamilton, Louise Ander, Andrew Marriott and Andrew Dunne (all BGS) and Giovanni Leonardi, Rebecca Close, Helen Crabbe, Karen Exley, Amy Rimell and Mike Studden (all PHE) for their involvement in the wider project. We thank Nigel Kendall and David Gardner from the University of Nottingham Biosciences for facilitating creatinine and osmolality measurements. Murray Lark, Chris Milne, Mark Cave and Simon Chenery from the BGS are thanked for advice Publisher Copyright: {\textcopyright} 2016 Taylor & Francis Group, London. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; 6th International Congress on Arsenic in the Environment, AS 2016 ; Conference date: 19-06-2016 Through 23-06-2016",

year = "2016",

doi = "10.1201/b20466-190",

language = "English",

isbn = "9781138029415",

series = "Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016",

publisher = "CRC Press/Balkema",

pages = "406--408",

editor = "Prosun Bhattacharya and Gunnar Jacks and Jochen Bundschuh and Prosun Bhattacharya and Marie Vahter and Jerker Jarsjo and Jerker Jarsjo and Jurate Kumpiene and Arslan Ahmad and Charlotte Sparrenbom and Donselaar, {Marinus Eric} and Jochen Bundschuh and Ravi Naidu and Ravi Naidu",

booktitle = "Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016",

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Middleton, DRS, Watts, MJ, Fletcher, A & Polya, DA 2016, A modified creatinine adjustment method to improve urinary biomonitoring of exposure to arsenic in drinking water. in P Bhattacharya, G Jacks, J Bundschuh, P Bhattacharya, M Vahter, J Jarsjo, J Jarsjo, J Kumpiene, A Ahmad, C Sparrenbom, ME Donselaar, J Bundschuh, R Naidu & R Naidu (eds), Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016, CRC Press/Balkema, pp. 406-408, 6th International Congress on Arsenic in the Environment, AS 2016, Stockholm, Sweden, 19/06/16. https://doi.org/10.1201/b20466-190

A modified creatinine adjustment method to improve urinary biomonitoring of exposure to arsenic in drinking water. / Middleton, D. R.S.; Watts, M. J.; Fletcher, Antony et al.
Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. ed. / Prosun Bhattacharya; Gunnar Jacks; Jochen Bundschuh; Prosun Bhattacharya; Marie Vahter; Jerker Jarsjo; Jerker Jarsjo; Jurate Kumpiene; Arslan Ahmad; Charlotte Sparrenbom; Marinus Eric Donselaar; Jochen Bundschuh; Ravi Naidu; Ravi Naidu. CRC Press/Balkema, 2016. p. 406-408 (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A modified creatinine adjustment method to improve urinary biomonitoring of exposure to arsenic in drinking water

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AU - Watts, M. J.

AU - Fletcher, Antony

AU - Polya, D. A.

N1 - Funding Information: DRSM was funded by NERC via a University of Manchester/BUFI (Centre for Environmental Geochemistry) PhD studentship (GA/125/017, BUFI Ref: S204.2). We thank Elliott Hamilton, Louise Ander, Andrew Marriott and Andrew Dunne (all BGS) and Giovanni Leonardi, Rebecca Close, Helen Crabbe, Karen Exley, Amy Rimell and Mike Studden (all PHE) for their involvement in the wider project. We thank Nigel Kendall and David Gardner from the University of Nottingham Biosciences for facilitating creatinine and osmolality measurements. Murray Lark, Chris Milne, Mark Cave and Simon Chenery from the BGS are thanked for advice Publisher Copyright: © 2016 Taylor & Francis Group, London. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2016

Y1 - 2016

N2 - Spot urinary concentrations of arsenic (As) require adjustment for hydration variation. There is no consensus as to the most appropriate method. We compared the performance of creatinine (Cre), specific gravity (SG), osmolality and a modified variant of Cre adjustment on spot urinary As concentrations of 203 volunteers from the UK. Strength in correlation between drinking water total As and urinary non-arsenobetaine As was used to indicate good performance. Performance of the order: Cre (modified) > SG > osmolality > unadjusted > Cre (routine) was observed. Only Cre (modified) adjustment performed significantly better than unadjusted concentrations and both Cre (modified) and SG performed significantly better than Cre (routine). This is the first study to compare the performance of multiple hydration adjustments of urinary As on the basis of reflectance of external exposure and, importantly, allows others to apply this methodology to existing data without further measurements.

AB - Spot urinary concentrations of arsenic (As) require adjustment for hydration variation. There is no consensus as to the most appropriate method. We compared the performance of creatinine (Cre), specific gravity (SG), osmolality and a modified variant of Cre adjustment on spot urinary As concentrations of 203 volunteers from the UK. Strength in correlation between drinking water total As and urinary non-arsenobetaine As was used to indicate good performance. Performance of the order: Cre (modified) > SG > osmolality > unadjusted > Cre (routine) was observed. Only Cre (modified) adjustment performed significantly better than unadjusted concentrations and both Cre (modified) and SG performed significantly better than Cre (routine). This is the first study to compare the performance of multiple hydration adjustments of urinary As on the basis of reflectance of external exposure and, importantly, allows others to apply this methodology to existing data without further measurements.

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M3 - Conference contribution

AN - SCOPUS:85016991464

SN - 9781138029415

T3 - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

SP - 406

EP - 408

BT - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

A2 - Bhattacharya, Prosun

A2 - Jacks, Gunnar

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A2 - Bhattacharya, Prosun

A2 - Vahter, Marie

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A2 - Kumpiene, Jurate

A2 - Ahmad, Arslan

A2 - Sparrenbom, Charlotte

A2 - Donselaar, Marinus Eric

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PB - CRC Press/Balkema

T2 - 6th International Congress on Arsenic in the Environment, AS 2016

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Middleton DRS, Watts MJ, Fletcher A, Polya DA. A modified creatinine adjustment method to improve urinary biomonitoring of exposure to arsenic in drinking water. In Bhattacharya P, Jacks G, Bundschuh J, Bhattacharya P, Vahter M, Jarsjo J, Jarsjo J, Kumpiene J, Ahmad A, Sparrenbom C, Donselaar ME, Bundschuh J, Naidu R, Naidu R, editors, Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema. 2016. p. 406-408. (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016). doi: 10.1201/b20466-190

A modified creatinine adjustment method to improve urinary biomonitoring of exposure to arsenic in drinking water

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