TY - JOUR
T1 - A minimal common outcome measure set for COVID-19 clinical research
AU - WHO Working Group on the Clinical Characterisation and Management of COVID-19 infection
AU - Marshall, John C.
AU - Murthy, Srinivas
AU - Diaz, Janet
AU - Adhikari, Neil
AU - Angus, Derek C.
AU - Arabi, Yaseen M.
AU - Baillie, Kenneth
AU - Bauer, Michael
AU - Berry, Scott
AU - Blackwood, Bronagh
AU - Bonten, Marc
AU - Bozza, Fernando
AU - Brunkhorst, Frank
AU - Cheng, Allen
AU - Clarke, Mike
AU - Dat, Vu Quoc
AU - de Jong, Menno
AU - Denholm, Justin
AU - Derde, Lennie
AU - Dunning, William
AU - Feng, Xiaobin
AU - Fletcher, Tom
AU - Foster, Nadine
AU - Fowler, Rob
AU - Gobat, Nina
AU - Gomersall, Charles
AU - Gordon, Anthony
AU - Glueck, Thomas
AU - Harhay, Michael
AU - Hodgson, Carol
AU - Horby, Peter
AU - Kim, Yae Jean
AU - Kojan, Richard
AU - Kumar, Bharath
AU - Laffey, John
AU - Malvey, Denis
AU - Martin-Loeches, Ignacio
AU - McArthur, Colin
AU - McAuley, Danny
AU - McBride, Stephen
AU - McGuinness, Shay
AU - Merson, Laura
AU - Morpeth, Susan
AU - Needham, Dale
AU - Netea, Mihai
AU - Oh, Myoung Don
AU - Phyu, Sabai
AU - Piva, Simone
AU - Qiu, Ruijin
AU - Salisu-Kabara, Halima
N1 - Funding Information:
Supported in part by a grant from the Canadian Institutes of Health Research.
Publisher Copyright:
© 2020 Elsevier Ltd
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - Clinical research is necessary for an effective response to an emerging infectious disease outbreak. However, research efforts are often hastily organised and done using various research tools, with the result that pooling data across studies is challenging. In response to the needs of the rapidly evolving COVID-19 outbreak, the Clinical Characterisation and Management Working Group of the WHO Research and Development Blueprint programme, the International Forum for Acute Care Trialists, and the International Severe Acute Respiratory and Emerging Infections Consortium have developed a minimum set of common outcome measures for studies of COVID-19. This set includes three elements: a measure of viral burden (quantitative PCR or cycle threshold), a measure of patient survival (mortality at hospital discharge or at 60 days), and a measure of patient progression through the health-care system by use of the WHO Clinical Progression Scale, which reflects patient trajectory and resource use over the course of clinical illness. We urge investigators to include these key data elements in ongoing and future studies to expedite the pooling of data during this immediate threat, and to hone a tool for future needs.
AB - Clinical research is necessary for an effective response to an emerging infectious disease outbreak. However, research efforts are often hastily organised and done using various research tools, with the result that pooling data across studies is challenging. In response to the needs of the rapidly evolving COVID-19 outbreak, the Clinical Characterisation and Management Working Group of the WHO Research and Development Blueprint programme, the International Forum for Acute Care Trialists, and the International Severe Acute Respiratory and Emerging Infections Consortium have developed a minimum set of common outcome measures for studies of COVID-19. This set includes three elements: a measure of viral burden (quantitative PCR or cycle threshold), a measure of patient survival (mortality at hospital discharge or at 60 days), and a measure of patient progression through the health-care system by use of the WHO Clinical Progression Scale, which reflects patient trajectory and resource use over the course of clinical illness. We urge investigators to include these key data elements in ongoing and future studies to expedite the pooling of data during this immediate threat, and to hone a tool for future needs.
UR - http://www.scopus.com/inward/record.url?scp=85086916476&partnerID=8YFLogxK
U2 - 10.1016/S1473-3099(20)30483-7
DO - 10.1016/S1473-3099(20)30483-7
M3 - Review article
C2 - 32539990
AN - SCOPUS:85086916476
VL - 20
SP - e192-e197
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
SN - 1473-3099
IS - 8
ER -