TY - JOUR
T1 - A comparison of the bactericidal and photobactericidal activities of aminoacridines and bis(aminoacridines)
AU - Wainwright, M.
AU - Phoenix, D. A.
AU - Marland, J.
AU - Wareing, D. R.A.
AU - Bolton, F. J.
PY - 1998
Y1 - 1998
N2 - An attempt was made to increase the:activity of some antibacterial acridines in two ways: (a) via the use of bis-aminacrines (analogues of 1,6-bis-[9-acridinamino]hexane), in order to increase the potential for DNA intercalation and (b) via photoactivation, as several acridines are known to produce the cytotoxin singlet oxygen on irradiation. The bactericidal activity of the simple aminoacridines was much higher than that of the corresponding bis-acridine compounds. In addition, on low-power illumination of die compounds in liquid culture, many of the monomeric compounds exhibited marked increases in activity against both Gram-negative and Gram-positive bacteria, whereas the bisacridines showed little or no increase.
AB - An attempt was made to increase the:activity of some antibacterial acridines in two ways: (a) via the use of bis-aminacrines (analogues of 1,6-bis-[9-acridinamino]hexane), in order to increase the potential for DNA intercalation and (b) via photoactivation, as several acridines are known to produce the cytotoxin singlet oxygen on irradiation. The bactericidal activity of the simple aminoacridines was much higher than that of the corresponding bis-acridine compounds. In addition, on low-power illumination of die compounds in liquid culture, many of the monomeric compounds exhibited marked increases in activity against both Gram-negative and Gram-positive bacteria, whereas the bisacridines showed little or no increase.
UR - http://www.scopus.com/inward/record.url?scp=0031815330&partnerID=8YFLogxK
U2 - 10.1046/j.1472-765X.1998.00357.x
DO - 10.1046/j.1472-765X.1998.00357.x
M3 - Article
C2 - 9717309
AN - SCOPUS:0031815330
SN - 0266-8254
VL - 26
SP - 404
EP - 406
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
IS - 6
ER -