A comparison of aztreonam/metronidazole and cefotaxime/metronidazole in elective colorectal surgery: Antimicrobial prophylaxis must include gram-positive cover

D. L. Morris; S. Rodgers Wilson; J. Pain; K. F. Edwardson; J. Jones; C. Strachan; R. Slack

doi:10.1093/jac/25.4.673

A comparison of aztreonam/metronidazole and cefotaxime/metronidazole in elective colorectal surgery: Antimicrobial prophylaxis must include gram-positive cover

D. L. Morris^*, S. Rodgers Wilson, J. Pain, K. F. Edwardson, J. Jones, C. Strachan, R. Slack

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Aztreonam/metronidazole and cefotaxime/metronidazole were compared in a prospective trial in 154 patients undergoing elective colorectal surgery. Three antibiotic doses were given over 16 hours. A significant excess of wound sepsis in the aztreonam group was seen (23/71 vs 9/70 _ξ² 6·60; P < 0.01). Sepsis was almost invariably due to Gram-positive organisms and, in particular, Staphylococcus aureus.

Original language	English
Pages (from-to)	673-678
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	25
Issue number	4
DOIs	https://doi.org/10.1093/jac/25.4.673
Publication status	Published - Apr 1990

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abstract = "Aztreonam/metronidazole and cefotaxime/metronidazole were compared in a prospective trial in 154 patients undergoing elective colorectal surgery. Three antibiotic doses were given over 16 hours. A significant excess of wound sepsis in the aztreonam group was seen (23/71 vs 9/70 ξ2 6·60; P < 0.01). Sepsis was almost invariably due to Gram-positive organisms and, in particular, Staphylococcus aureus.",

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AU - Edwardson, K. F.

AU - Jones, J.

AU - Strachan, C.

AU - Slack, R.

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AB - Aztreonam/metronidazole and cefotaxime/metronidazole were compared in a prospective trial in 154 patients undergoing elective colorectal surgery. Three antibiotic doses were given over 16 hours. A significant excess of wound sepsis in the aztreonam group was seen (23/71 vs 9/70 ξ2 6·60; P < 0.01). Sepsis was almost invariably due to Gram-positive organisms and, in particular, Staphylococcus aureus.

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A comparison of aztreonam/metronidazole and cefotaxime/metronidazole in elective colorectal surgery: Antimicrobial prophylaxis must include gram-positive cover

Abstract

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