A collaborative exercise on cytogenic dosimetry for simulated whole and partial body accidental irradiation

D. C. Lloyd; Alan Edwards; J. S. Prosser; N. Barjaktarovic; J. K. Brown; D. Horvat; S. R. Ismail; G. J. Köteles; Z. Almassy; A. Krepinsky; M. Kucerova; L. G. Littlefield; U. Mukherjee; A. T. Natarajan; M. S. Sasaki

doi:10.1016/0027-5107(87)90310-1

A collaborative exercise on cytogenic dosimetry for simulated whole and partial body accidental irradiation

D. C. Lloyd^*
, Alan Edwards
, J. S. Prosser
, N. Barjaktarovic
, J. K. Brown
, D. Horvat
, S. R. Ismail
, G. J. Köteles
, Z. Almassy
, A. Krepinsky
, M. Kucerova
, L. G. Littlefield
, U. Mukherjee
, A. T. Natarajan
, M. S. Sasaki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

An experiment sponsored by the International Atomic Energy Agency was undertaken to compare dose estimation by cytogenetic analysis on aliquots of samples of irradiated blood sent by air to participating laboratories. Accidental acute whole-body irradiations to 0.7 and 2.34 Gy and half-body irradiations to 3.5 Gy were simulated with X- and γ-rays. For the partial irradiations the size of the irradiated fraction and its dose were estimated by the Qdr and contaminated Poisson techniques. Each laboratory's in vitro dose-response data were fitted to the quadratic model by the iteratively reweighted least squares method. Interlaboratory variations in dose-response curves, and in the aberration yields and dose estimates for the simulated accidents were noted. However, in general, most participants consistently obtained results acceptably close to the true values.

Original language	English
Pages (from-to)	197-208
Number of pages	12
Journal	Mutation Research
Volume	179
Issue number	2
DOIs	https://doi.org/10.1016/0027-5107(87)90310-1
Publication status	Published - Aug 1987

Bibliographical note

Funding Information:
An experiment sponsored by the International Atomic Energy Agency was undertaken to compare dose estimation by cytogenetic analysis on aliquots of samples of irradiated blood sent by air to participating laboratories. Accidental acute whole-body irradiations to 0.7 and 2.34 Gy and half-body irradiations to 3.5 Gy were simulated with X-and ,/-rays. For the partial irradiations the size of the irradiated fraction and its dose were estimated by the Qdr and contaminated Poisson techniques. Each laboratory's in vitro dose-response data were fitted to the quadratic model by the iteratively reweighted least squares method.

Funding Information:
With the support of a Coordinated Research Programme of the International Atomic Energy Agency, a number of cytogenetic laboratories in developing countries have been encouraged to produce in vitro X-and/or y-radiation dose-response curves for the induction of chromosome aberrations in human peripheral blood lymphocytes. These data will enable the laboratories to perform biological dosimetry on samples of blood

Keywords

Chromosome aberration dosimetry
Partial body irradiation
Radiation accident

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10.1016/0027-5107(87)90310-1

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Lloyd, D. C., Edwards, A., Prosser, J. S., Barjaktarovic, N., Brown, J. K., Horvat, D., Ismail, S. R., Köteles, G. J., Almassy, Z., Krepinsky, A., Kucerova, M., Littlefield, L. G., Mukherjee, U., Natarajan, A. T., & Sasaki, M. S. (1987). A collaborative exercise on cytogenic dosimetry for simulated whole and partial body accidental irradiation. Mutation Research, 179(2), 197-208. https://doi.org/10.1016/0027-5107(87)90310-1

@article{1c5578762cf64b3aa52b14418848d7f3,

title = "A collaborative exercise on cytogenic dosimetry for simulated whole and partial body accidental irradiation",

abstract = "An experiment sponsored by the International Atomic Energy Agency was undertaken to compare dose estimation by cytogenetic analysis on aliquots of samples of irradiated blood sent by air to participating laboratories. Accidental acute whole-body irradiations to 0.7 and 2.34 Gy and half-body irradiations to 3.5 Gy were simulated with X- and γ-rays. For the partial irradiations the size of the irradiated fraction and its dose were estimated by the Qdr and contaminated Poisson techniques. Each laboratory's in vitro dose-response data were fitted to the quadratic model by the iteratively reweighted least squares method. Interlaboratory variations in dose-response curves, and in the aberration yields and dose estimates for the simulated accidents were noted. However, in general, most participants consistently obtained results acceptably close to the true values.",

keywords = "Chromosome aberration dosimetry, Partial body irradiation, Radiation accident",

author = "Lloyd, \{D. C.\} and Alan Edwards and Prosser, \{J. S.\} and N. Barjaktarovic and Brown, \{J. K.\} and D. Horvat and Ismail, \{S. R.\} and K{\"o}teles, \{G. J.\} and Z. Almassy and A. Krepinsky and M. Kucerova and Littlefield, \{L. G.\} and U. Mukherjee and Natarajan, \{A. T.\} and Sasaki, \{M. S.\}",

note = "Funding Information: An experiment sponsored by the International Atomic Energy Agency was undertaken to compare dose estimation by cytogenetic analysis on aliquots of samples of irradiated blood sent by air to participating laboratories. Accidental acute whole-body irradiations to 0.7 and 2.34 Gy and half-body irradiations to 3.5 Gy were simulated with X-and ,/-rays. For the partial irradiations the size of the irradiated fraction and its dose were estimated by the Qdr and contaminated Poisson techniques. Each laboratory's in vitro dose-response data were fitted to the quadratic model by the iteratively reweighted least squares method. Funding Information: With the support of a Coordinated Research Programme of the International Atomic Energy Agency, a number of cytogenetic laboratories in developing countries have been encouraged to produce in vitro X-and/or y-radiation dose-response curves for the induction of chromosome aberrations in human peripheral blood lymphocytes. These data will enable the laboratories to perform biological dosimetry on samples of blood",

year = "1987",

month = aug,

doi = "10.1016/0027-5107(87)90310-1",

language = "English",

volume = "179",

pages = "197--208",

journal = "Mutation Research",

issn = "0027-5107",

publisher = "Elsevier BV",

number = "2",

}

Lloyd, DC, Edwards, A, Prosser, JS, Barjaktarovic, N, Brown, JK, Horvat, D, Ismail, SR, Köteles, GJ, Almassy, Z, Krepinsky, A, Kucerova, M, Littlefield, LG, Mukherjee, U, Natarajan, AT & Sasaki, MS 1987, 'A collaborative exercise on cytogenic dosimetry for simulated whole and partial body accidental irradiation', Mutation Research, vol. 179, no. 2, pp. 197-208. https://doi.org/10.1016/0027-5107(87)90310-1

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T1 - A collaborative exercise on cytogenic dosimetry for simulated whole and partial body accidental irradiation

AU - Lloyd, D. C.

AU - Edwards, Alan

AU - Prosser, J. S.

AU - Barjaktarovic, N.

AU - Brown, J. K.

AU - Horvat, D.

AU - Ismail, S. R.

AU - Köteles, G. J.

AU - Almassy, Z.

AU - Krepinsky, A.

AU - Kucerova, M.

AU - Littlefield, L. G.

AU - Mukherjee, U.

AU - Natarajan, A. T.

AU - Sasaki, M. S.

N1 - Funding Information: An experiment sponsored by the International Atomic Energy Agency was undertaken to compare dose estimation by cytogenetic analysis on aliquots of samples of irradiated blood sent by air to participating laboratories. Accidental acute whole-body irradiations to 0.7 and 2.34 Gy and half-body irradiations to 3.5 Gy were simulated with X-and ,/-rays. For the partial irradiations the size of the irradiated fraction and its dose were estimated by the Qdr and contaminated Poisson techniques. Each laboratory's in vitro dose-response data were fitted to the quadratic model by the iteratively reweighted least squares method. Funding Information: With the support of a Coordinated Research Programme of the International Atomic Energy Agency, a number of cytogenetic laboratories in developing countries have been encouraged to produce in vitro X-and/or y-radiation dose-response curves for the induction of chromosome aberrations in human peripheral blood lymphocytes. These data will enable the laboratories to perform biological dosimetry on samples of blood

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N2 - An experiment sponsored by the International Atomic Energy Agency was undertaken to compare dose estimation by cytogenetic analysis on aliquots of samples of irradiated blood sent by air to participating laboratories. Accidental acute whole-body irradiations to 0.7 and 2.34 Gy and half-body irradiations to 3.5 Gy were simulated with X- and γ-rays. For the partial irradiations the size of the irradiated fraction and its dose were estimated by the Qdr and contaminated Poisson techniques. Each laboratory's in vitro dose-response data were fitted to the quadratic model by the iteratively reweighted least squares method. Interlaboratory variations in dose-response curves, and in the aberration yields and dose estimates for the simulated accidents were noted. However, in general, most participants consistently obtained results acceptably close to the true values.

AB - An experiment sponsored by the International Atomic Energy Agency was undertaken to compare dose estimation by cytogenetic analysis on aliquots of samples of irradiated blood sent by air to participating laboratories. Accidental acute whole-body irradiations to 0.7 and 2.34 Gy and half-body irradiations to 3.5 Gy were simulated with X- and γ-rays. For the partial irradiations the size of the irradiated fraction and its dose were estimated by the Qdr and contaminated Poisson techniques. Each laboratory's in vitro dose-response data were fitted to the quadratic model by the iteratively reweighted least squares method. Interlaboratory variations in dose-response curves, and in the aberration yields and dose estimates for the simulated accidents were noted. However, in general, most participants consistently obtained results acceptably close to the true values.

KW - Chromosome aberration dosimetry

KW - Partial body irradiation

KW - Radiation accident

UR - https://www.scopus.com/pages/publications/0023387510

U2 - 10.1016/0027-5107(87)90310-1

DO - 10.1016/0027-5107(87)90310-1

M3 - Article

C2 - 3302692

AN - SCOPUS:0023387510

SN - 0027-5107

VL - 179

SP - 197

EP - 208

JO - Mutation Research

JF - Mutation Research

IS - 2

ER -

A collaborative exercise on cytogenic dosimetry for simulated whole and partial body accidental irradiation

Abstract

Bibliographical note

Keywords

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