A case of wild-type rubella-associated cutaneous granuloma in ataxia telangiectasia

Rachel Browne*, Lucy Cliffe, Winne Ip, Kevin Brown, Elizabeth McDermott

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Granulomatous skin disease is known to be associated with various primary immunodeficiencies, including ataxia telangiectasia (AT). Recent reports of persistence of live vaccine strain rubella within such cutaneous granulomas have raised concern regarding the safety of vaccination. Here we report a case of cutaneous granuloma in association with AT, demonstrating wild type, rather than vaccine strain rubella. This supports the persistence of rubella as a causative mechanism, but suggests it is not vaccine strain-specific, and thus may impact the decision of those considering not vaccinating this subset of children.

Original languageEnglish
JournalPediatric Dermatology
DOIs
Publication statusAccepted/In press - 2022

Bibliographical note

Publisher Copyright:
© 2022 Wiley Periodicals LLC.

Keywords

  • ataxia telangiectasia
  • cutaneous granuloma
  • granulomatous skin disease
  • immunodeficiency
  • rubella

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