A brief review of influenza virus infection

Mostafa Javanian, Mohammad Barary, Sam Ghebrehewet, Veerendra Koppolu, Veneela Krishna Rekha Vasigala, Soheil Ebrahimpour*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    6 Citations (Scopus)


    Influenza is an acute viral respiratory infection that affects all age groups and is associated with high mortality during pandemics, epidemics, and sporadic outbreaks. Nearly 10% of the world's population is affected by influenza annually, with about half a million deaths each year. Influenza vaccination is the most effective method for preventing influenza infection and its complications. The influenza vaccine's efficacy varies each season based on the circulating influenza strains and vaccine uptake rates. Currently, three antiviral drugs targeting the influenza virus surface glycoprotein neuraminidase are available for treatment and prophylaxis of disease. Given the significant burden of influenza infection globally, this review is focused on the latest findings in the etiology, epidemiology, transmission, clinical manifestation, diagnosis, prevention, and treatment of influenza.

    Original languageEnglish
    Pages (from-to)4638-4646
    Number of pages9
    JournalJournal of Medical Virology
    Issue number8
    Early online date14 Apr 2021
    Publication statusPublished - 25 Jun 2021

    Bibliographical note

    Funding Information:
    The authors thank the Department of Infectious Diseases of Babol University of Medical Sciences.

    Open Access: No open Access licence.

    Publisher Copyright: © 2021 Wiley Periodicals LLC

    Citation: Javanian, M, Barary, M, Ghebrehewet, S, Koppolu, V, Vasigala, V, Ebrahimpour, S. A brief review of influenza virus infection. J Med Virol. 2021; 93: 4638- 4646.

    DOI: https://doi.org/10.1002/jmv.26990


    • antiviral agents
    • epidemiology
    • influenza virus, treatment


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