A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium

Research output: Contribution to journalArticlepeer-review

143 Citations (Scopus)

Abstract

Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated comparison with influenza and sepsis patients versus healthy volunteers. We identify immune signatures and correlates of host response. Hallmarks of disease severity involved cells, their inflammatory mediators and networks, including progenitor cells and specific myeloid and lymphocyte subsets, features of the immune repertoire, acute phase response, metabolism, and coagulation. Persisting immune activation involving AP-1/p38MAPK was a specific feature of COVID-19. The plasma proteome enabled sub-phenotyping into patient clusters, predictive of severity and outcome. Systems-based integrative analyses including tensor and matrix decomposition of all modalities revealed feature groupings linked with severity and specificity compared to influenza and sepsis. Our approach and blood atlas will support future drug development, clinical trial design, and personalized medicine approaches for COVID-19.

Original languageEnglish
Pages (from-to)916-938.e58
Number of pages82
JournalCell
Volume185
Issue number5
DOIs
Publication statusPublished - 3 Mar 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 The Author

Keywords

  • COVID-19
  • SARS-CoV-2
  • blood
  • coronavirus
  • epigenetics
  • immune
  • multi-omics
  • personalized medicine
  • proteomics
  • transcriptomics

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