A black mould death: A case of fatal cerebral phaeohyphomycosis caused by Cladophialophora bantiana

Sarah Howlett; Tadhg Sullivan; Alireza Abdolrasouli; Andrew M. Borman; Elizabeth M. Johnson; Paul Lewis; Aravindhan Baheerathan; Frances Davies; Frances Sanderson; Nicholas Davies; Victoria Singh-Curry

doi:10.1016/j.mmcr.2019.02.004

A black mould death: A case of fatal cerebral phaeohyphomycosis caused by Cladophialophora bantiana

Sarah Howlett^*
, Tadhg Sullivan
, Alireza Abdolrasouli
, Andrew M. Borman
, Elizabeth M. Johnson
, Paul Lewis
, Aravindhan Baheerathan
, Frances Davies
, Frances Sanderson
, Nicholas Davies
, Victoria Singh-Curry

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Cladophialophora bantiana is a neurotropic mould and primary cause of cerebral phaeohyphomycoses, which presents with brain abscesses in both immunocompromised and immunocompetent individuals. It is associated with high mortality due to delay in diagnosis and absence of standardised therapy. We present a case of fatal cerebral phaeohyphomycosis in a 67-year-old Caucasian man. Diagnosis was achieved by histopathological examination of brain tissue followed by conventional culture and molecular identification. We highlight diagnostic and treatment challenges involved.

Original language	English
Pages (from-to)	23-26
Number of pages	4
Journal	Medical Mycology Case Reports
Volume	24
DOIs	https://doi.org/10.1016/j.mmcr.2019.02.004
Publication status	Published - Jun 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cerebral phaeohyphomycoses
Cladophialophora bantiana
Dematiaceous fungi
Gene sequencing

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10.1016/j.mmcr.2019.02.004

Cite this

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title = "A black mould death: A case of fatal cerebral phaeohyphomycosis caused by Cladophialophora bantiana",

abstract = "Cladophialophora bantiana is a neurotropic mould and primary cause of cerebral phaeohyphomycoses, which presents with brain abscesses in both immunocompromised and immunocompetent individuals. It is associated with high mortality due to delay in diagnosis and absence of standardised therapy. We present a case of fatal cerebral phaeohyphomycosis in a 67-year-old Caucasian man. Diagnosis was achieved by histopathological examination of brain tissue followed by conventional culture and molecular identification. We highlight diagnostic and treatment challenges involved.",

keywords = "Cerebral phaeohyphomycoses, Cladophialophora bantiana, Dematiaceous fungi, Gene sequencing",

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note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = jun,

doi = "10.1016/j.mmcr.2019.02.004",

language = "English",

volume = "24",

pages = "23--26",

journal = "Medical Mycology Case Reports",

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TY - JOUR

T1 - A black mould death

T2 - A case of fatal cerebral phaeohyphomycosis caused by Cladophialophora bantiana

AU - Howlett, Sarah

AU - Sullivan, Tadhg

AU - Abdolrasouli, Alireza

AU - Borman, Andrew M.

AU - Johnson, Elizabeth M.

AU - Lewis, Paul

AU - Baheerathan, Aravindhan

AU - Davies, Frances

AU - Sanderson, Frances

AU - Davies, Nicholas

AU - Singh-Curry, Victoria

PY - 2019/6

Y1 - 2019/6

N2 - Cladophialophora bantiana is a neurotropic mould and primary cause of cerebral phaeohyphomycoses, which presents with brain abscesses in both immunocompromised and immunocompetent individuals. It is associated with high mortality due to delay in diagnosis and absence of standardised therapy. We present a case of fatal cerebral phaeohyphomycosis in a 67-year-old Caucasian man. Diagnosis was achieved by histopathological examination of brain tissue followed by conventional culture and molecular identification. We highlight diagnostic and treatment challenges involved.

AB - Cladophialophora bantiana is a neurotropic mould and primary cause of cerebral phaeohyphomycoses, which presents with brain abscesses in both immunocompromised and immunocompetent individuals. It is associated with high mortality due to delay in diagnosis and absence of standardised therapy. We present a case of fatal cerebral phaeohyphomycosis in a 67-year-old Caucasian man. Diagnosis was achieved by histopathological examination of brain tissue followed by conventional culture and molecular identification. We highlight diagnostic and treatment challenges involved.

KW - Cerebral phaeohyphomycoses

KW - Cladophialophora bantiana

KW - Dematiaceous fungi

KW - Gene sequencing

UR - https://www.scopus.com/pages/publications/85062227109

U2 - 10.1016/j.mmcr.2019.02.004

DO - 10.1016/j.mmcr.2019.02.004

M3 - Article

AN - SCOPUS:85062227109

SN - 2211-7539

VL - 24

SP - 23

EP - 26

JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

ER -

A black mould death: A case of fatal cerebral phaeohyphomycosis caused by Cladophialophora bantiana

Abstract

Bibliographical note

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Keywords

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