中国大陆女性HPV感染危险因素的Meta分析

Objective To learn and evaluate the risk factors of HPV infection among women in mainland China, and provide reference for the prevention and control. Methods Relevant studies on the risk factors of HPV infection published in PubMed, CNKI, VIP and WanFang databases from January 1, 1995 to December 31, 2020 were comprehensively retrieved for systematic analysis. Two researchers independently screened the literatures, extracted data and evaluated the quality of the literatures included in the study, then analyzed them with Stata 12.0 software. Results A total of 48 literatures were included in the study, involving a total of 210 009 cases. There were 26 653 cases of HPV infection. The results of analysis model showed the following OR (95% CI) values: Number of pregnancies >1: 1.14 (1.07-1.20); Number of births >1: 1.35 (1.06-1.74); Number of abortions > 1: 1.30 (0.97-1.74); Contraceptive pills: 1.11 (0.91-1.34); Condoms: 0.56 (0.35-0.89); IUD contraception: 1.02 (0.91-1.13); Trichomonas vaginitis: 1.33 (1.04-1.69); Cervical erosion: 2.2 (1.03-4.70); Smoking: 1.28 (1.09-1.51); Drinking: 1.15 (1.07-1.24); Education of junior high school and below: 1.03 (0.74-1.44); Unemployed: 0.94 (0.73-1.21); Married: 0.60 (0.47-0.78); Number of marriages > 1: 1.47 (1.25-1.73); Number of sexual partners > 1: 1.96 (1.46-2.62); Husband's extramarital sexual relationships: 1.68 (1.35-2.09); Number of husband's sex partners > 1: 2.14 (1.45-3.15); Frequency of sexual life > 2 times/week: 1.37(0.79-2.37); Menopause: 1.65(1.11-2.46); Age of first intercourse ≤20 years: 1.48 (1.23-1.78). Conclusion The major risk factors of HPV infection include the number of pregnancy and birth, trichomonas vaginitis, cervical erosion, smoking, drinking, excessive number of marriages, multiple sexual partners, husband's extramarital sexual behavior, husband's multiple sexual partners, menopause and premature first sexual life, while the protective factors are marriage and condom.