SIREN

The SARS-CoV-2 Immunity and Reinfection EvaluatioN (SIREN) study is a prospective cohort study of hospital-based healthcare workers across the UK. It was established in 2020 as a pandemic response study, with over 44,000 healthcare workers recruited from 135 NHS trusts/health boards. The study initially investigated SARS-CoV-2 reinfections and the durability of immunity following infection, and subsequently COVID-19 vaccination. It has expanded its scope to evaluate Winter Pressures on the healthcare workforce, and questions of immunity more broadly. SIREN study - GOV.UK (www.gov.uk)

Key Workstreams

• Monitoring SARS-CoV-2 and respiratory infections and assessing risk factors for infection in UK healthcare workers
• Evaluating protection following infection and vaccination
• Pandemic preparedness
• Understanding immunity around SARS-CoV-2 and other respiratory viruses
• Quantifying the impact of Winter Pressures on the NHS workforce
• Exploring the burden of AMR and the microbiome in healthcare workers
• Mixed-methods research and evaluation
• Participant involvement in research

Collaborations

• World Health Organisation (Europe Region)
• The Francis Crick Institute
• The Wellcome Sanger Institute
• University College London
• University of Cardiff
• University of Cambridge
• University of Oxford
• University of Liverpool
• University of Sheffield
• Newcastle University
• University of Birmingham
• Birmingham City University
• Imperial College London
• University of Glasgow
• University of Edinburgh
• Pirbright Institute
• British Society of Immunology
• Seromyx

Data and Samples Accessibility Statement

All data is stored in a centralised database, including questionnaires, testing and all data from collaborations. We are committed to making the anonymised SIREN dataset available to researchers, within appropriate ethical and information governance guidelines.

We aim to develop the SIREN biobank into an accessible resource for the public health and medical research community, ensuring adherence to ethical and data protection safeguards.

For more information, please contact the SIREN team at: [email protected]