Research output per year
Research output per year
Organisation profile
Organisation profile
The SARS-CoV-2 Immunity and Reinfection EvaluatioN (SIREN) study is a prospective cohort study of hospital-based healthcare workers across the UK. It was established in 2020 as a pandemic response study, with over 44,000 healthcare workers recruited from 135 NHS trusts/health boards. The study initially investigated SARS-CoV-2 reinfections and the durability of immunity following infection, and subsequently COVID-19 vaccination. It has expanded its scope to evaluate Winter Pressures on the healthcare workforce, and questions of immunity more broadly. SIREN study - GOV.UK (www.gov.uk)
Key Workstreams
- Monitoring SARS-CoV-2 and respiratory infections and assessing risk factors for infection in UK healthcare workers
- Evaluating protection following infection and vaccination
- Pandemic preparedness
- Understanding immunity around SARS-CoV-2 and other respiratory viruses
- Quantifying the impact of Winter Pressures on the NHS workforce
- Exploring the burden of AMR and the microbiome in healthcare workers
- Mixed-methods research and evaluation
- Participant involvement in research
Fingerprint
Dive into the research topics where SIREN Study Team is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Effectiveness of BNT162b2 mRNA vaccine third doses and previous infection in protecting against SARS-CoV-2 infections during the Delta and Omicron variant waves; the UK SIREN cohort study September 2021 to February 2022
the SIREN Study Group, Jan 2024, In: Journal of Infection. 88, 1, p. 30-40 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort
SIREN Study Group, Jan 2024, In: The Lancet Regional Health - Europe. 36, 100809.Research output: Contribution to journal › Article › peer-review
Open Access -
Prevalence and impact of persistent symptoms following SARS-CoV-2 infection among healthcare workers: A cross-sectional survey in the SIREN cohort
SIREN Study Group, Oct 2024, In: Journal of Infection. 89, 4, 106259.Research output: Contribution to journal › Article › peer-review
Open Access